Figure 4.

Clinically used SPIO for MFH consist of aminosilane surface modified 10 nm iron oxide nanoparticles. (A) TEM images of 3-aminopropyltriethoxysilane coated iron oxide particles that are highly mono-disperse (scale bar = 20 nm)(Reproduced with permission from ¹⁰¹ Copyright 2010 IEEE) (B) Aggregated and chained nanoparticle configurations can improve the effective SAR value (500 W g^-1 at 89 kA m^-1 AC magnetic field and 240 kHz frequency)) (scale bar = 200 nm). Reproduced with permission from ¹⁰² Copyright 2011 The Royal Society of Chemistry. (C) TEM images reveal the aminosilane coated nanoparticles are endocytosed and adhere strongly on the surface of the cancerous cells (arrows), greatly increasing the chances of localizing the heat (scale bar = 5 µm) ¹⁰³, ¹⁰⁴ (Reproduced with permission from ¹⁰⁶ Copyright 2019 Elsevier).