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. 2020 Feb 7;14(3):657–668. doi: 10.1002/1878-0261.12628

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© 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Antitumor activity of the oncolytic adenovirus SG635‐SF is CD47‐dependent. (A) Immunohistochemistry results revealed growth inhibition, CD47 expression blockade, macrophage‐mediated phagocytosis, and viral infiltration enhancement of the oncolytic adenovirus SG635‐SF compared to other treatments. (B) Oncolytic adenovirus SG635‐SF inhibited the growth of the CD47‐positive HO8910 cell‐derived xenografts more strongly than SG635. Values are mean ± SD (n = 7); Pearson's chi‐square test was used; ***P < 0.001 vs SG635 group. (C) The inhibition ability of oncolytic adenovirus SG635‐SF had no significant difference compared with the group of SG635 in CD47‐negative HepG2 cell‐derived xenografts. Values are mean ± SD.