Fig. 5.

Representative hematoxylin and eosin (H&E) histological sections of the cardiac tissue of (A) DOX showing rupture of cardiac muscle fibers (black arrows in A₁), hemorrhage (white arrow in A₂) myocyte wavy degeneration (angled arrows in A₃), necrosis and inter-fibrillar congestion (black arrow in A₄). (B) Dexrazoxane (50 mg/kg) showing mild hemorrhage (black arrow). (C) Vanillic acid at dose of 10 mg/kg showing mild inter-fibrillar congestion (white arrowhead) and mild wavy degeneration (black arrowhead). (D and E) Vanillic acid at doses of 20 and 40 mg/kg and (F) normal saline control group, showing normal cardiac tissue architecture; ×40 magnification.