Table 2.

Effect of VA and DEX on serum level of cardiac enzyme biomarkers. Values are mean ± SEM, n = 6.

Groups (mg/kg)	LDH activity (IU/L)	SGOT activity (IU/L)	CK-MB activity(IU/L)
Normal saline	114 ± 15.9	67 ± 4.8	191 ± 25.2
DOX	378 ± 32.56###	93 ± 7.8###	448 ± 33.1###
DEX + DOX	200 ± 30.1***	65 ± 10***	240 ±16.2***
VA10 + DOX	277 ± 22***	87 ± 5.6**	275 ± 28*
VA20 + DOX	221 ± 18***	76 ±10.3***	204 ± 30***
VA40 + DOX	211 ± 25***	65 ± 5.8***	202 ± 48***

VA, Vanillic acid; DEX, dexrazoxane; DOX, doxorubicin; LDH, lactate dehydrogenase; SGOT, serum glutamic oxaloacetic transaminase; CK-MB, creatine phosphokinase-MB; ^###P < 0.001 indicates significant differences in comparison with normal saline control, *P < 0.05, **P < 0.01, and ***P < 0.001 versus DOX group