Table 2.

Predicted regulatory processes and gene counts targeted by the deregulated miRNAs in oxidative-stressed MSC

Regulatory process	miRNA expression	Gene count
Gene regulation
GO:0000978~RNA pol II core promoter proximal region sequence-specific DNA binding	Up	23
GO:0001078~Transcriptional repressor activity, RNA pol II core promoter proximal region sequence -specific binding	Up	6
GO:0003676~Nucleic acid binding	Up	38
GO:0000289~Nuclear-transcribed mRNA poly(A) tail shortening	Down	4
GO:0045787~Positive regulation of cell cycle	Down	5
GO:0035194~Posttranscriptional gene silencing by RNA	Down	4
GO:0035278~miRNA mediated inhibition of translation	Down	5
	Total	85 (32.9%)
Kinase activity and signaling
GO:0008589~Regulation of smoothened signaling pathway	Up	4
GO:0038083~Peptidyl-tyrosine autophosphorylation	Up	6
GO:0045747~Positive regulation of Notch signaling pathway	UP	4
GO:0004674~Protein serine/threonine kinase activity	Down	20
GO:0004709~MAP kinase kinase kinase activity	Down	4
GO:0004715~Non-membrane spanning protein tyrosine kinase activity	Down	4
	Total	42 (16.3%)
Cell cycle
GO:0045787~Positive regulation of cell cycle	Down	5
	Total	5 (1.9%)

Data is extracted from the biological and molecular processes in the gene ontology analysis of the significantly and differentially expressed miRNAs in OSIPS cells as presented in Supplementary Table S3. Combining the up- and down-regulated biological and molecular processes, there are 258 genes; the percentages shown in brackets are percentages of the total gene counts.