Table 1.
Genetic polymorphism distributions of the metastasis-associated in colon cancer-1 gene in Taiwanese women with neoplasias of the uterine cervix and normal controls
| Genetic polymorphisms | Normal controls (n =338) | Cervical neoplasiasa (n=231) | ORs (95% CIs) | p values | AORs (95% CIs)b | Adjusted p valuesb |
|---|---|---|---|---|---|---|
| rs975263 | 0.511 | 0.532 | ||||
| AAc | 228 | 158 | 1.00 | 1.00 | ||
| AG | 94 | 67 | 1.03 (0.71-1.49) | 0.883 | 1.03 (0.70-1.52) | 0.891 |
| GG | 15 | 6 | 0.58 (0.22-1.52) | 0.266 | 0.58 (0.21-1.55) | 0.275 |
| AAc | 228 | 158 | 1.00 | 0.852 | 1.00 | |
| AG/GG | 109 | 73 | 0.97 (0.68-1.38) | 0.96 (0.66-1.40) | 0.844 | |
| AA/AGc | 322 | 225 | 1.00 | 0.250 | 1.00 | |
| GG | 15 | 6 | 0.57 (0.22-1.50) | 0.57 (0.21-1.53) | 0.265 | |
| rs3095007 | 0.682 | 0.691 | ||||
| GGc | 282 | 198 | 1.00 | 1.00 | ||
| GT | 53 | 30 | 0.81 (0.50-1.31) | 0.382 | 0.81 (0.49-1.34) | 0.401 |
| TT | 3 | 2 | 0.95 (0.16-5.74) | 0.955 | 0.81 (0.12-5.30) | 0.826 |
| GGc | 282 | 198 | 1.00 | 0.391 | 1.00 | |
| GT/TT | 56 | 32 | 0.81 (0.51-1.30) | 0.81 (0.49-1.32) | 0.390 | |
| GG/GTc | 335 | 228 | 1.00 | 1.000 | 1.00 | |
| TT | 3 | 2 | 0.98 (0.16-5.91) | 0.84 (0.13-5.46) | 0.852 | |
| rs4721888 | 0.237 | 0.169 | ||||
| GGc | 186 | 114 | 1.00 | 1.00 | ||
| GC | 126 | 103 | 1.33 (0.94-1.89) | 0.106 | 1.41 (0.98-2.04) | 0.064 |
| CC | 24 | 14 | 0.95 (0.47-1.92) | 0.890 | 1.03 (0.50-2.12) | 0.948 |
| GGc | 186 | 114 | 1.00 | 0.159 | 1.00 | |
| GC/CC | 150 | 117 | 1.27 (0.91-1.78) | 1.35 (0.95-1.92) | 0.093 | |
| GG/GCc | 312 | 217 | 1.00 | 0.613 | 1.00 | |
| CC | 24 | 14 | 0.84 (0.42-1.66) | 0.88 (0.43-1.79) | 0.725 | |
| rs3735615 | 0.326 | |||||
| GGc | 236 | 167 | 1.00 | 1.00 | 0.366 | |
| GC | 89 | 61 | 0.97 (0.66-1.42) | 0.870 | 0.98 (0.66-1.46) | 0.929 |
| CC | 11 | 3 | 0.39 (0.11-1.40) | 0.148 | 0.39 (0.10-1.44) | 0.156 |
| GGc | 236 | 167 | 1.00 | 0.596 | 1.00 | |
| GC/CC | 100 | 64 | 0.90 (0.62-1.31) | 0.91 (0.62-1.35) | 0.647 | |
| GG/GCc | 325 | 228 | 1.00 | 0.136 | 1.00 | |
| CC | 11 | 3 | 0.39 (0.11-1.41) | 0.39 (0.11-1.44) | 0.157 | |
| rs1990172 | 0.606 | 0.602 | ||||
| CCc | 245 | 177 | 1.00 | 1.00 | ||
| CA | 82 | 49 | 0.83 (0.55-1.24) | 0.356 | 0.83 (0.54-1.26) | 0.372 |
| AA | 9 | 5 | 0.77 (0.25-2.33) | 0.643 | 0.73 (0.23-2.28) | 0.588 |
| CCc | 245 | 177 | 1.00 | 0.320 | 1.00 | |
| CA/AA | 91 | 54 | 0.82 (0.56-1.21) | 0.82 (0.54-1.22) | 0.323 | |
| CC/CAc | 327 | 226 | 1.00 | 0.698 | 1.00 | |
| AA | 9 | 5 | 0.80 (0.27-2.43) | 0.76 (0.25-2.37) | 0.640 |
Statistical analysis: logistic regression model or chi-square or Fisher's exact tests. aCervical neoplasias included precancerous lesions and invasive cancer of the uterine cervix.
bThe adjusted p values as well as adjusted odds ratios and their 95% confident intervals were calculated by logistic regression model after controlling age. cUsed as a reference for comparison to calculate the odds ratios of other genotypes. 95% CIs, 95% confidence intervals.