Table 4.
Univariate analysis for the impact of metastasis-associated in colon cancer-1 gene polymorphisms and various clinicopatholgical parameters on the 5 years survival rate
| Variables | 5 years survival rate & 95% CI | 5 years survival hazard | |
|---|---|---|---|
| P value | HR and 95% CIb | ||
| metastasis-associated in colon cancer-1 gene polymorphisms | |||
| rs975263 | |||
| AG/GG vs AAa | 0.89 (0.79-0.99) vs 0.79 (0.70-0.88) | 0.195 | 0.49 (0.16-1.45) |
| GG vs AA/AGa | 0.80 (0.45-1.00) vs 0.82 (0.75-0.90) | 0.897 | 1.14 (0.15-8.54) |
| rs3095007 | |||
| GT/TT vs GGa | 0.83 (0.62-1.00) vs 0.82 (0.74-0.90) | 0.761 | 0.80 (0.19-3.44) |
| TT vs GG/GTa | 0.50 (0.00-1.00) vs 0.83 (0.76-0.90) | 0.254 | 3.23 (0.43-24.15) |
| rs4721888 | |||
| GC/CC vs GGa | 0.81 (0.71-0.91) vs 0.84 (0.74-0.93) | 0.651 | 1.23 (0.51-2.96) |
| CC vs GG/GCa | 0.89 (0.68-1.00) vs 0.82 (0.74-0.89) | 0.651 | 0.63 (0.08-4.70) |
| rs3735615 | |||
| GC/CC vs GGa | 0.90 (0.79-1.00) vs 0.80 (0.71-0.88) | 0.193 | 0.44 (0.13-1.51) |
| CC vs GG/GCa | 0.50 (0.00-1.00) vs 0.83 (0.76-0.90) | 0.254 | 3.23 (0.43-24.15) |
| rs1990172 | |||
| CA/AA vs CCa | 0.89 (0.76-1.00) vs 0.81 (0.72-0.89) | 0.395 | 0.59 (0.17-2.00) |
| AA vs CC/CAa | 0.75 (0.33-1.00) vs 0.83 (0.75-0.90) | 0.702 | 1.48 (0.20-11.07) |
| Clinical stage | |||
| ≥ stage II vs stage Ia | 0.70 (0.57-0.83) vs 0.91 (0.84-0.98) | 0.008 | 3.64 (1.40-9.47) |
| Pathologic type | |||
| adenocarcinoma vs squamous cell carcinomaa | 0.68 (0.45-0.92) vs 0.84 (0.77-0.92) | 0.129 | 2.19 (0.80-6.03) |
| Cell grading | |||
| moderate & poor (grades 2/3) vs well (grade 1)a | 0.82 (0.740-0.90) vs 0.82 (0.64-1.00) | 0.916 | 0.94 (0.27-3.20) |
| Stromal invasion depth | |||
| >10 mm vs ≤10 mma | 0.72 (0.61-0.84) vs 0.93 (0.86-1.00) | 0.009 | 4.39 (1.45-13.23) |
| Tumor diameter | |||
| >4 cm vs ≤ 4cma | 0.71 (0.59-0.84) vs 0.92 (0.85-0.99) | 0.009 | 3.83 (1.39-10.55) |
| Parametrium | |||
| invasion vs no invasiona | 0.68 (0.54-0.83) vs 0.90 (0.83-0.97) | 0.009 | 3.42 (1.36-8.57) |
| Vagina | |||
| invasion vs no invasiona | 0.75 (0.61-0.90) vs 0.85 (0.77-0.93) | 0.240 | 1.70 (0.70-4.10) |
| Pelvic lymph node | |||
| metastasis vs no metastasisa | 0.53 (0.35-0.71) vs 0.93 (0.87-0.98) | <0.001 | 7.99 (3.07-20.82) |
Statistical analyses: Kaplan-Meier curve model. aAs a comparison reference. bHR, hazard ratio and 95% CI, 95% confidence interval for metastasis-associated in colon cancer-1 genetic variants and clinicopathological variables, compared to their respective controls.