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. 2020 Feb 10;16(7):1264–1273. doi: 10.7150/ijbs.38415

Figure 5.

Figure 5

S587R-SASH1 enhanced cellular migration and adhesion abilities, suppressed melanin biosynthesis in PIG1 cells. (A) Wound-healing assays demonstrated 2.04 fold and 1.77 fold increase in S587R-SASH1 transfected PIG1 cells, as compared to WT-SASH1 and S507A-SASH1 cells. (B) Transwell migration assay revealed 2.05 fold and 1.67 fold increase in the number of S587R-SASH1 PIG1 cells that migrated after a 24 h period, as compared to WT-SASH1 and S507A-SASH1 cells. (C) SASH1 mutants obviously reduced the melanin content to 53.1% and 54.6%, as compared to that in WT-SASH1 and S507A-SASH1.