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. 2020 Feb 10;16(7):1252–1263. doi: 10.7150/ijbs.38835

Figure 5.

Figure 5

EHMT2 suppresses autophagic death of primary HAVSMCs by regulating SQSTM1 and BECN1 expression. A. The growth curve of primary HAVSMCs stimulated with BIX01294 for indicated times (n=3). *p<0.05 vs. DMSO. B. The protein levels of SQSTM1, BECN1, and LC3 were evaluated by western blot in primary HAVSMCs treated with BIX01294 or DMSO for 24h (n=4). C. H3K9me1, H3K9me2, SQSTM1, BECN1, and LC3 protein levels in primary HAVSMCs with EHMT2 knockdown or its counterparts (n=4). D. The growth curve of primary HAVSMCs treated with indicated stimulations (n=3). *p<0.05 vs. lenti-shRNA+ BIX01294. E and F. The LC3 protein levels were detected by western blot in primary HAVSMCs treated with indicated stimulations (n=4). Histone H3 serves as a loading control.