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. 2020 Feb 10;16(7):1238–1251. doi: 10.7150/ijbs.39768

Figure 4.

Figure 4

Axl-148b conjugate prevents breast tumor dissemination in mice. (A) Scheme of the experiment: Red fluorescent (RFP-expressing) 4175-TGL cells were injected into the mammary gland fat pad of NOD/SCID/IL2R null mice and PBS or axl, axl-148b or scr-148b aptamers were administered into the tumors starting at day 9 post-injection, when masses were palpable, (3 treatments/week, 300 pmol in 100 µl, 10 injections in total, as indicated) and lung/liver metastases and CTCs were evaluated 32 days post-tumor-cell injections. (B-D) Total number of lung/liver metastases or fluorescent CTCs are presented as mean±SEM for the indicated number (n) of mice. Representative images of lung/liver metastases or fluorescent CTCs are also shown. Arrows point to metastases. CTCs = Circulating Tumor Cells. scr= scramble. * p< 0.05, ** p< 0.01, *** p < 0.001. SEM = Standard Error of Mean. Scale bar=800 µm (B-C) or 50 µm (D).