Skip to main content
. 2020 Feb 10;16(7):1207–1217. doi: 10.7150/ijbs.39779

Figure 7.

Figure 7

THZ1 suppressed the growth of patient-derived ICC xenografts. A. IHC staining of CDK7 in PDX0044 tumors. Scale bar= 50 μm. B. Images of PDX tumors derived from mice (n=6) treated with either PBS or THZ1 (10 mg/kg, twice a day for 17 days). C. Tumor growth curves of mice (n=6) treated with either PBS or THZ1 (10 mg/kg, twice a day for 17 days). Tumor volume was monitored at 4-day intervals. D. Weight of PDX tumors derived from mice (n=6) treated with either PBS or THZ1 (10 mg/kg, twice a day for 17 days). E. Body weight of the mice (n=6). F. Serum ALT, AST, and BUN levels in mice in the different groups. G. Hematoxylin and eosin (H&E) staining of the major organs (heart, lung, liver, spleen, and kidney) of mice in the different groups. The results are presented as mean ± SD of three independent experiments (*P<0.05, **P<0.01, ***P<0.001, according to a Student's t-test).