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Synovitis precedes cartilage degradation and angiopoiesis during the pathogenesis of surgically-induced OA. Knee joints were harvested at different time points of 1, 2, 4, 8, or 12 weeks after surgery as indicated. Hematoxylin-eosin staining results showed synovitis (yellow arrow) in the DMM surgery group one week after surgery, and cartilage degradation (black arrow) and angiopoiesis (black arrowhead) 4 weeks after DMM surgery. Scale bar, 50 μm. n = 5.
