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. 2020 Feb 4;16(6):1071–1085. doi: 10.7150/ijbs.41230

Figure 8.

Figure 8

Knockdown or inhibition of the CPCM components repressed tumor cell growth in vivo. (A) The knockdown of the CPCM components reduced tumor volumes in vivo. The HT29, c-Myc-KD, CARM1-KD and p300-KD cells were injected into nude mice (n=5 for each cell line) to generate tumors. Tumor volumes were measured in a five-day interval. **P < 0.01. (B) Inhibition of the CPCM components reduced tumor volumes in vivo. The HT29 cells were injected into nude mice and then mice were randomly assigned to four groups (n = 5 in each group). Mice were injected with PBS, 5 μM sAJM, 20 μM CARM-IN-1 or 50 nM C646 every five days. Tumor volumes were measured in a five-day interval. **P < 0.01. (C and D) Knockdown or inhibition of the CPCM components caused the decrease of CUL4A/4B but increase of ST7 in vivo. Tumors from (A) and (B) were subjected to examine protein levels of c-Myc, Max, CARM1, p300, CUL4A, CUL4B, and ST7. GADPH was used as a loading control.