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Diagram showing physiological production of Calcitonin (A) and production of PCT in sepsis states (B). As depicted, PCT is not typically secreted into the bloodstream in normal physiological conditions whereas multiple tissues can secrete PCT in sepsis. Once in the bloodstream, PCT cannot be degraded. CT-mRNA: Calcitonin messenger RNA, Pre-PCT: Pre-procalcitonin, PCT: Pro-calcitonin, N-ProCT: N termical Pro-calcitonin, CT: Calcitonin
