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Conceptual hypothesis showing the relationship between worm reproductive senescence, concomitant immunity, and host infection. Over the course of infection in a host: (A) Schistosomes infect a naïve host. (B) Established adult worms prevent new infections via concomitant immunity, and produce eggs that induce pathology. (C) Older worms still prevent new infections via concomitant immunity, but produce few to no eggs due to reproductive senescence. Artwork: Kate Lamy.
