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. 2020 Feb 25;11:301. doi: 10.3389/fimmu.2020.00301

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Copyright © 2020 Häusler, Torke and Weber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interference with calcium mobilization. Therapeutic intervention with calcium mobilization can target the initial release of calcium from the endoplasmic reticulum (ER), for example by interfering with the ryanodine receptor (RyR). Alternatively, the interaction of stromal interaction molecule 1 (STIM1) with CRAC modulator 1 (CRACM1) can be disturbed by reactive oxygen species (ROS). Most available drugs target voltage-gated calcium channels (Ca_v).