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. 2020 Feb 25;11:130. doi: 10.3389/fphys.2020.00130

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Copyright © 2020 Keddar, Muylle, Carrie, Trefois, Nachit, Crott, Christiaens, Bammens, Jadoul, Goffin and Morelle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal changes in muscle radiation attenuation during time on dialysis. (A) Individual changes (gray thin lines) and mean values (red thick line) of MRA during time on dialysis. (B) Mean (± SD) values of MRA during the first, second, and third years on dialysis (*P = 0.03 for linear trend, one-way ANOVA). (C,D) Illustrative longitudinal data of fat distribution, residual kidney function, and serum p-cresyl sulfate levels from two individuals on long-term PD: a 39-year-old woman on PD for 4 years (patient 1) and a 66-year-old man on PD for 5 years (patient 2). In both patients, a significant decrease in mean MRA (from 37.0 to 24.0 HU in patient 1 and from 37.6 to 27.2 HU in patient 2) paralleled the loss in residual function and accumulation of circulating p-cresyl sulfate.