Table 3:

Change in Sleep and Neuropsychological Performance Parameters over 12 Weeks in Switch Study Subjects by Arm

	EFV/FTC/TDF (Atripla) Continuation Arm (N = 10)ǂ	EVG/COBI/FTC/TDF (Stribild) Switch Arm (N = 22)Ɨ	P-Value*	Effect SizeƗƗ
Baseline to Week 12 Change: Sleep Parameters
Sleep Efficiency	−0.2 (−18.1, 8.6)	0 (−6.0, 3.7)	0.92	0.01
Sleep Maintenance Efficiency	1.5 (−5.8, 7.6)	−0.8 (−1.9, 3.8)	0.76	0.05
Sleep Latency, minutes	0.5 (−1.0, 28.0)	−2.5 (−10.0, 12.3)	0.36	0.17
Sleep Arousal Index (SAI)	−1.2 (−1.7, −0.5)	−0.3 (−4.6, 1.6)	0.51	−0.12
Wake After Sleep Onset (WASO), percent	−1.4 (−12.3, 8.4)	0.8 (−4.2, 1.9)	0.74	−0.05
REM Sleep, percent	1.9 (−3.8, 3.6)	0.1 (−3.8, 4.9)	1.00	0
Stage 3 Sleep, percent	−1.6 (−2.4, 2.6)	0 (−3.7, 1.6)	0.98	0
Apnea-Hypopnea Index	2.9 (0.6, 4.0)	0.9 (−1.7, 4.3)	0.13	0.28
Respiratory Disturbance Index	4.3 (2.6, 9.1)	3.0 (−2.7, 5.2)	0.20	0.24
Epworth Sleepiness Scale	−0.5 (−2.0, 4.0)	0 (−3.0, 2.0)	0.67	0.07
PSQI Total Score	0 (−1.0, 1.0)	−1.0 (−2.0, 1.0)	0.54	0.11
Baseline to Week 12 Change: Neuropsychological Z-Scores
NPZ Global	0.2 (−0.04, 0.35)	0.08 (−0.16, 0.34)	0.50	0.12
NPZ Learning and Memory	0.46 (−0.03, 1.03)	0.27 (−0.04, 0.77)	0.52	0.11
NPZ Executive Function	0.08 (−0.03, 0.63)	0.15 (0.02, 0.54)	0.52	−0.11
NPZ Working Memory	0.08 (−0.05, 0.55)	0.16 (−0.47, 0.63)	0.54	0.11
NPZ Psychomotor Speed	0.02 (−0.13, 0.24)	−0.06 (−0.28, 0.34)	0.68	0.07

Median change (quartile 1, quartile 3) presented. Wilcoxon Rank Sum test used to assess changes between groups. PSQI = Pittsburgh Sleep Quality Index. REM = Rapid Eye Movement.

^ƗStribild Arm: N = 20 with available entry and week 12 neuropsychological data; N = 20 with available entry and week 12 sleep data.

^ǂAtripla Arm: N = 10 with available entry and week 12 neuropsychological data; N = 9 with available entry and week 12 sleep data.

^*Wilcoxon rank sum test used to compare continuous variables.

^ƗƗWilcoxon Z statistic transformed to effect size r_W, r_W = Z/√N.