Table 2.
Reactivation parameters determined for selected aldoximes and human BChE inhibited by cyclosarin and sarin. The results are expressed as mean ± S.E. calculated from at least three experiments. Maximal percentage of reactivation (Reactmax) and the time (t) in which it was achieved were also determined.
| Inhibitor | Oxime | k2 / min−1 | Kox / μM | kr / M−1 min−1 | Reactmax / % | t / min |
|---|---|---|---|---|---|---|
| Cyclosarin | 1d | 0.40 ± 0.02 | 66 ± 8.0 | 6250 ± 55 | 80 | 10 |
| 2d | 0.21 ± 0.02 | 67 ± 16 | 3050 ± 520 | 70 | 30 | |
| HI-6 | 1.4 ± 0.27 | 1410 ± 390 | 1010 ± 95.0 | 90 | 30 | |
| 2-PAM | 0.08 ± 0.01 | 1200 ± 240.0 | 65 ± 10 | 80 | 60 | |
| Sarin | 1e | 0.11± 0.013 | 800 ± 170 | 140 ± 14 | 80 | 60 |
| 2e | 0.058 ± 0.014 | 410 ± 250 | 140 ± 50 | 60 | 60 | |
| 2b | 0.022 ± 0.0033 | 195 ± 89.0 | 110 ± 35 | 70 | 120 | |
| 1b | 0.030 ± 0.003 | 365 ± 84.0 | 70 ± 10 | 90 | 180 | |
| HI-6 | 0.041 ± 0.019 | 270 ± 200 | 150 ± 40 | 100 | 300 | |
| 2-PAM | 0.18 ± 0.05 | 2400 ± 995.0 | 75 ± 10 | 100 | 120 | |