Table 2.
Survival, weight, fat mass, and glucose level table.
| Study (author, year) | Exp # | Species | Obesity model | Weight (g) | Fat mass (g) | Glucose (mg/dl) | Control | Obese | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Type | GT/DC | Control | Obese | Control | Obese | Control | Obese | Tot | Surv | Rep | Tot | Surv | |||
| Single-strain bacteria models | |||||||||||||||
| Hsu, 2007 | 1 | Mo | Gen | ob/ob | NR | NR | NR | NR | NR | NR | 10 | 9 | 1 | 17 | 3 |
| 2 | Mo | Gen | ob/ob/lep | NR | NR | NR | NR | NR | NR | 10 | 9 | 1 | 18 | 8 | |
| Strandberg, 2009 | 3 | Mo | Gen | ob/ob | 28.8 ± 0.5 | 39.3 ± 1.1 | NR | NR | NR | NR | 15 | 12 | 0 | 18 | 5 |
| 4 | Mo | DIO | HFD | 28.8 ± 0.5 | 39.3 ± 1.1 | 5.5 ± 0.2 | 17.0 ± 0 | NR | NR | 21 | 18 | 0 | 18 | 8 | |
| Mancuso, 2014 | 5 | Mo | Gen | CPEF/F | 20 ± 0.5 | 47.5 ± 1 | NR | NR∗ | 120 ± 5 | 180 ± 5 | 6 | 2 | 0 | 6 | 3 |
| Svahn, 2015 | 6 | Mo | DIO | HFDP | 30 ± 1 | 35 ± 1 | 7.0 ± 0.5 | 14 ± 0.5 | NR | NR | 20 | 13 | 1 | 20 | 17 |
| 7 | Mo | DIO | HFDS | 30 ± 1 | 45 ± 1 | 7.0 ± 0.5 | 20.0 ± 0.5 | NR | NR | 20 | 13 | 1 | 20 | 4 | |
| 8 | Mo | DIO | HFDS-HP | 30 ± 1 | 45 ± 1 | 14.05 ± 0.5 | 20.0 ± 0.5 | NR | NR | 20 | 16 | 0 | 20 | 8 | |
| 9 | Mo | DIO | HFDS-LP | 30 ± 1 | 45 ± 1 | 14.05 ± 0.5 | 20.0 ± 0.5 | NR | NR | 20 | 17 | 0 | 20 | 8 | |
| Svahn, 2016 | 10 | Mo | DIO | HFDS | 39 ± 1 | 45 ± 1 | 15 ± 0.5 | 20.0 ± 0.5 | NR | NR | 20 | 14 | 1 | 20 | 3 |
| 11 | Mo | DIO | HFDw6 | 39 ± 1 | 42.5 ± 1 | 15 ± 0.5 | 20.0 ± 0.5 | NR | NR | 20 | 14 | 1 | 20 | 8 | |
| Wan, 2016 | 12 | Mo | DIO | HFD | 37.5 ± 1 | 47.5 ± 1 | NR | NR | 225 ± 40 | 350 ± 25 | 18 | 18 | 0 | 18 | 18 |
| 13 | Mo | DIO | HFD | 37.5 ± 1 | 47.5 ± 1 | NR | NR | 225 ± 40 | 350 ± 25 | 18 | 15 | 0 | 18 | 10 | |
| Cecal ligation and puncture models | |||||||||||||||
| Tschop, 2010 | 14 | Mo | Gen | ob/ob | NR | NR | NR | NR | NR | NR | 20 | 4 | 1 | 20 | 0 |
| 15 | Mo | DIO | HFD | NR | NR | NR | NR | NR | NR | 20 | 4 | 1 | 7 | 4 | |
| 16 | Mo | Gen | ob/ob | NR | NR | NR | NR | NR | NR | 11 | 3 | 0 | 11 | 0 | |
| Kaplan, 2012 | 17 | Mo | DIO | HFD | 23.4 ± 0.4 | 25.2 ± 0.4 | MRI∗ | MRI-inc∗ | NR | NR | 12 | 6 | 0 | 12 | 1 |
| Siegl, 2014 | 18 | Mo | DIO | HFD | 27.7 ± 0.2 | 34.4 ± 0.5 | NR | NR | NR | NR | 10 | 1 | 0 | 14 | 10 |
| Kaplan, 2016 | 19 | Mo | DIO | HFD | 27 ± 0.5 | 33 ± 1 | 2 ± 0.5 | 9.6 ± 2 | 165 ± 5 | 190 ± 5 | 12 | 4 | 0 | 12 | 2 |
| Lipopolysaccharide | |||||||||||||||
| Fagioni, 1998 | 20 | Mo | Gen | ob/ob | 20 | 40 | NR | NR | 100 ± 5 | 190 ± 5 | 5 | 5 | 0 | 5 | 3 |
| 21 | Mo | Gen | ob/ob | 20 | 40 | NR | NR | 100 ± 5 | 190 ± 5 | 5 | 5 | 0 | 5 | 2 | |
| 22 | Mo | Gen | ob/ob | 20 | 40 | NR | NR | 100 ± 5 | 190 ± 5 | 5 | 4 | 0 | 5 | 0 | |
| 23 | Mo | Gen | db/db | 20 | 40 | NR | NR | 110 ± 5 | 310 ± 50 | 5 | 4 | 0 | 5 | 4 | |
| 24 | Mo | Gen | db/db | 20 | 40 | NR | NR | 110 ± 5 | 310 ± 50 | 5 | 1 | 0 | 5 | 1 | |
| 25 | Mo | Gen | db/db | 20 | 40 | NR | NR | 110 ± 5 | 310 ± 50 | 5 | 0 | 0 | 5 | 0 | |
| Segersvard, 2003 | 26 | Ra | DIO | HFD35 | 415 ± 9 | 436 ± 8 | 3.4 ± 0.2∗∗ | 5.2 ± 0.2∗∗ | NR | NR | 12 | 10 | 1 | 16 | 9 |
| 27 | Ra | DIO | HFD60 | 415 ± 9 | 466 ± 5 | 3.4 ± 0.2∗∗ | 6.2 ± 0.2∗∗ | NR | NR | 12 | 10 | 1 | 16 | 10 | |
| Suto, 2007 | 28 | Mo | Gen | B6AY12- | 19.6 | 25.1 | NR | NR | NR | NR | 20 | 20 | 0 | 20 | 18 |
| 29 | Mo | Gen | B6Ay12- | 19.6 | 25.1 | NR | NR | NR | NR | 20 | 17 | 1 | 20 | 7 | |
| 30 | Mo | Gen | B6-ob/ob | 19.6 | 52.8 | NR | NR | NR | NR | 20 | 17 | 1 | 24 | 0 | |
| 31 | Mo | Gen | B6Ay12- | 19.6 | 25.1 | NR | NR | NR | NR | 15 | 6 | 0 | 15 | 0 | |
| 32 | Mo | Gen | B6Ay10m | 19.6 | 51 | NR | NR | NR | NR | 6 | 2 | 0 | 5 | 0 | |
| 33 | Mo | Gen | B6Ay10m | 19.6 | 51 | NR | NR | NR | NR | 11 | 2 | 0 | 10 | 0 | |
| Sakai, 2013 | 34 | Ra | DIO | HFD | 289 ± 3.5 | 310.6 ± 1.9 | 3.2 ± 0.3∗∗ | 6.8 ± 0.3∗∗ | 102.0 ± 2.2 | 116 ± 3.7 | 7 | 6 | 0 | 8 | 1 |
| Fujiwara, 2014 | 35 | Ra | DIO | HFD | 275 ± 1 | 294 ± 2.8 | NR | NR | NR | NR | 10 | 9 | 0 | 10 | 9 |
| 36 | Ra | DIO | HFD | 450 ± 1 | 504.4 ± 7.3 | NR | NR | NR | NR | 7 | 5 | 0 | 7 | 1 | |
| Single-strain virus models | |||||||||||||||
| Smith, 2007 | 37 | Mo | DIO | HFD | NR | NR | NR | NR | 86 ± 3 | 108 ± 9 | 18 | 17 | 0 | 18 | 10 |
| Easterbrook, 2011 | 38 | Mo | DIO | HFD | NR | NR | NR | NR | NR | NR | 5 | 5 | 0 | 5 | 1 |
| 39 | Mo | DIO | HFD | NR | NR | NR | NR | NR | NR | 5 | 5 | 0 | 5 | 5 | |
| 40 | Mo | DIO | HFD | NR | NR | NR | NR | NR | NR | 5 | 0 | 0 | 5 | 0 | |
| Milner, 2013 | 41 | Mo | DIO | HFD-UP | 30 ± 1 | 42.5 ± 1 | NR | NR | NR | NR | 4 | 0 | 0 | 4 | 0 |
| 42 | Mo | DIO | HFD-P | 30 ± 1 | 42.5 ± 1 | NR | NR | NR | NR | 46 | 46 | 0 | 46 | 44 | |
| Radigan, 2014 | 43 | Mo | Gen | db/db | 20–25 | 30–35 | NR | NR | NR | NR | 10 | 3 | 0 | 10 | 0 |
| 44 | Mo | Gen | db/db | 20–25 | 30–35 | NR | NR | NR | NR | 10 | 0 | 0 | 10 | 0 | |
| O'Brien, 2015 | 45 | Mo | DIO | HFD | 21 | 35 | NR | NR | NR | NR | 28 | 22 | 1 | 28 | 3 |
| 46 | Mo | Gen | ob/ob | 21 | 53 | NR | NR | NR | NR | 28 | 22 | 1 | 28 | 6 | |
| 47 | Mo | DIO | HFD | 21 | 35 | NR | NR | NR | NR | 28 | 21 | 1 | 28 | 0 | |
| 48 | Mo | Gen | ob/ob | 21 | 53 | NR | NR | NR | NR | 28 | 21 | 1 | 28 | 0 | |
| Milner, 2015 | 49 | Mo | DIO | HFD | 30 ± 1 | 42.5 ± 1 | NR | NR | 70 ± 5 | 105 ± 5 | 21 | 21 | 0 | 21 | 4 |
| 50 | Mo | DIO | HFD | 30 ± 1 | 42.5 ± 1 | NR | NR | 70 ± 5 | 105 ± 5 | 12 | 2 | 0 | 12 | 0 | |
| 51 | Mo | Gen | LepRH-/- | 30 ± 1 | 42.5 ± 1 | NR | NR | NR | NR | 20 | 18 | 0 | 10 | 5 | |
| 52 | Mo | Gen | LepRH-/- | 30 ± 1 | 42.5 ± 1 | NR | NR | NR | NR | 20 | 19 | 0 | 13 | 4 | |
Exp: experiment; db/db: leptin receptor-deficient mice; DC: diet composition; DIO: diet-induced obesity; Gen: genetic; GT: genotype; HFD: high-fat diet; Mo: mouse; NR: not recorded; ob/ob: leptin-deficient mice; Ra: Rat; Rep: repeating control animals; Surv: number of animals surviving; Tot: total number of animals studied; wk: week. ∗Noted increased fat mass on MRI but not quantitated; ∗∗total fat mass weights calculated based on animal total weights (see methods).