Table 3.
Effect of obesity compared to controls on parameters of organ injury.
| Author (year) | Exp # | Model | Site of infection | Significant changes in organ injury comparing obese and nonobese groups | Overall effect of obesity on measure of organ injury |
|---|---|---|---|---|---|
| Single-strain bacteria models | |||||
| Wan '16 | 12 | DIO | IN | Lung wet/dry ratio increased at 24 h with obesity | ↑ |
| 13 | DIO | IN | Lung wet/dry ratio increased at 24 and 96 h with obesity | ↑ | |
| Cecal ligation and puncture models | |||||
| Tschop '10 | 14 | Gen | IP | BUN as a marker of renal injury increased at 24 h with obesity ALT as a marker of liver injury increased at 24 h with obesity |
↑ |
| Kaplan '12 | 17 | DIO | IP | Histologic lung injury score increased at 6 h with obesity | ↑ |
| Kaplan '16 | 19 | DIO | IP | ALT as a marker of liver injury increased at 6 h with obesity | ↑ |
| Lipopolysaccharide | |||||
| Sakai '13 | 34 | DIO | IP | AST and liver histology score increased with obesity at 6 h | ↑ |
| Fujiwara ‘14 | 35 | DIO | IP | No significant differences in lung septal thickness or W/D at 6 h | NSD |
| 36 | DIO | IP | No significant differences in lung septal thickness or W/D at 6 h | NSD | |
| Single-strain virus models | |||||
| Smith ‘07 | 37 | DIO | IN | No significant difference in histologic lung injury score | NSD |
| Milner ‘13 | 42 | DIO | PO | Histologic lung injury increased at 5 d and BAL protein increased at 5 d and 6 d with obesity | ↑ |
| Radigan ‘14 | 43 | Gen | IT | BAL protein not significantly different at 4 d | NSD |
| 44 | Gen | IT | BAL protein significantly increased at 4 d with obesity | ↑ | |
| O'Brien | 45 | DIO | IN | Decreased lung epithelial regeneration and increased BAL albumin at 3 d and 6 d with obesity | ↑ |
| O'Brien | 46 | Gen | IN | Decreased lung epithelial regeneration and increased BAL albumin at 3 d and 6 d with obesity | ↑ |
| Milner ‘15 | 49 | DIO | IN | BAL protein and albumin increased at 4 d and BAL protein increased at 8 d with obesity | ↑ |
| 51 | Gen | IN | BAL protein increased at 8 d with obesity | ↑ | |
Exp: experiment; ALT: alanine aminotransferase; AST: aspartate aminotransferase; BAL: bronchoalveolar lavage; BUN: blood urea nitrogen; DIO: diet-induced obesity model; Gen: genetic model of obesity; NSD: no significant difference. ∗Remaining studies did not report organ injury data.