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. 2020 Feb 19;2020:8709804. doi: 10.1155/2020/8709804

Table 3.

Subgroup analysis based on Treg definitions.

Tregs definition	Analysis of Tregs/PBMCs						Analysis of Tregs/CD4⁺ T cells
Tregs definition	Number of studies (n)	SMD	95% CI	P ^a	I ² (%)	P ^b	Number of studies (n)	SMD	95% CI	P ^a	I ² (%)	P ^b
CD4⁺CD25^positive	14	−0.369	−0.493, −0.249	<0.001	91.6	<0.001	6	0.495	0.247, 0.742	<0.001	84.5	<0.001
CD4⁺CD25⁺	7	−0.395	−0.578, −0.212	<0.001	94.8	<0.001	2	0.606	0.113, 1.099	0.016	89.8	0.002
CD4⁺CD25^high	7	−0.347	−0.515, −0.178	<0.001	84.6	<0.001	4	0.457	0.171, 0.744	0.002	86.5	<0.001
CD4⁺CD25^positiveCD127^low/−	14	−0.912	−1.038, −0.786	<0.001	87.3	<0.001	—	—	—	—	—	—
CD4⁺CD25⁺CD127^low/−	4	−0.855	−1.065, −0.646	<0.001	51.2	0.105	4	−0.228	−0.488, 0.032	0.085	75.5	0.006
CD4⁺CD25^highCD127^low/−	10	−0.944	−1.101, −0.787	<0.001	90.6	<0.001	—	—	—	—	—	—
CD4⁺CD25⁺FoxP3⁺	12	−0.835	−0.995, −0.674	<0.001	93.2	<0.001	5	−0.494	−0.727, −0.261	<0.001	95.8	<0.001
CD3⁺CD4⁺FoxP3⁺	1	1.363	0.806, −1.919	<0.001	—	—	—	—	—	—	—	—
Treg	4	−1.460	−1.711, −1.208	<0.001	92.2	<0.001	1	−0.229	−0.365, −0.093	<0.001	—	—