Table 2.
Change in auxological and cardiovascular metabolic parameters before, during, and after GH treatment.
| Variable | Basal | 3 months | 6 months | 9 months | 1 year |
|---|---|---|---|---|---|
| BMI SDS | 2.38 ± 0.39ab | 2.23 ± 0.37 | 2.06 ± 0.43c | 2.00 ± 0.42 | 1.77 ± 0.50 |
| IGF-1 (μg/ml) | 243.44 | 676.98 | 709.43 | 727.00 | 818.44 |
| ±124.61ab | ±242.58 | ±214.72 | ±186.49 | ±192.96 | |
| TC (mmol/L) | 4.53 ± 0.61b | 3.90 ± 0.61 | 4.02 ± 0.47 | 3.83 ± 0.51 | 3.67 ± 0.38 |
| HDL-C (mmol/L) | 1.26 ± 0.24 | 1.35 ± 0.29 | 1.34 ± 0.30 | 1.39 ± 0.31 | 1.49 ± 0.38 |
| LDL-C (mmol/L) | 2.76 ± 0.46ab | 2.22 ± 0.36 | 2.10 ± 0.28c | 2.04 ± 0.42 | 1.71 ± 0.41 |
| TG (mmol/L) | 1.34 ± 0.65b | 1.16 ± 0.55 | 1.06 ± 0.52 | 0.92 ± 0.35 | 0.87 ± 0.35 |
| ALT (U/L) # | 31.24 ± 21.85ab | 19.36 ± 9.44 | 17.29 ± 16.02 | 15.17 ± 5.60 | 15.39 ± 4.94 |
| HbA1c (%) | 5.68 ± 0.26 | 5.67 ± 0.28 | 5.59 ± 0.25 | 5.62 ± 0.34 | 5.58 ± 0.26 |
| FBG (mmol/L) | 5.24 ± 0.33b | 5.62 ± 0.38 | 5.65 ± 0.52 | 5.41 ± 0.48 | 5.61 ± 0.51 |
| Insulin (μIU/mL)# | 24.34 ± 13.52 | 32.39 ± 13.07 | 29.06 ± 15.09 | 24.51 ± 11.51 | 23.66 ± 12.41 |
| HOMA-IR # | 5.67 ± 3.12 | 8.15 ± 3.60 | 7.39 ± 4.16 | 6.02 ± 3.06 | 5.97 ± 3.12 |
#P value reported for log-transformed values, but values in the table represent a back transformation. aP < 0.05 when GH treatment of 6 months was compared with baseline. bP < 0.05 when GH treatment of 1 year was compared with baseline. cP < 0.05 when GH treatment of 1 year was compared with GH treatment of 6 months.