Table 1. Statistical analysis.

Histopathological parameters were correlated with core status (Active/Transition/Exhausted) using pairwise t-tests with pooled standard deviation. Several histopathological parameters were correlated to the average level of activation of each core.

Parameter	Comparison	Statistical test	Multiple testing correction	p value
Brisk Infiltration	Brisk vs Non Brisk	t test	No	0.8453
Brisk Infiltration	Brisk vs Brisk In Non Brisk	pairwise t test	Yes	1
Brisk Infiltration	Brisk vs Non Brisk In Non Brisk	pairwise t test	Yes	1
Brisk Infiltration	Brisk In Non Brisk vs Non Brisk In Non Brisk	pairwise t test	Yes	1
Regression	Regression vs No Regression	t test	No	0.6275
Regression	Early Regression vs No Regression	pairwise t test	Yes	0.329
Regression	Late Regression vs No Regression	pairwise t test	Yes	0.031*
Regression	Late Regression vs Early Regression	pairwise t test	Yes	0.022*
Count Lymphocytes	Number of Lymphocytes vs Level of Activation	linear model	No	0.3714
Histotype	LMM vs NMM	pairwise t test	Yes	0.027*
Histotype	LMM vs SSMM	pairwise t test	Yes	0.021*
Histotype	NMM vs SSMM	pairwise t test	Yes	0.761
Breslow Thickness	Breslow vs Level of Activation	linear model	No	0.9883
Ulceration	Positive vs Negative	t test	No	0.7252
Number of Mitoses	More than 6 vs 1 to 6	pairwise t test	Yes	1
Number of Mitoses	More than 6 vs 0	pairwise t test	Yes	1
Number of Mitoses	one to 6 vs 0	pairwise t test	Yes	1