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. Author manuscript; available in PMC: 2020 Mar 3.
Published in final edited form as: Pain. 2019 Nov;160(11):2634–2640. doi: 10.1097/j.pain.0000000000001652

Figure 3.

Figure 3.

Morphine exacerbates CCI allodynia when dosing begins 10 days after injury. Chronic constriction injury surgeries were performed with one 6–0 chromic gut suture. Morphine (5 mg/kg twice per day) or equivolume saline was administered for 5 days, beginning at day 10 after surgery. (A) Von Frey testing was conducted before and after CCI surgery, and after completion of opioid administration. (B) Area-under-the-curve analysis of von Frey threshold of all timepoints after morphine treatment. BL: baseline, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. n = 6/group. CCI, chronic constriction injury.