Table 5.
Analysis of factors associated with complete eradication of dysplasia in Barrett’s esophagus
Factor | Unadjusted analysis | Adjusted analysis | ||
---|---|---|---|---|
OR (95% CI) | p-value | OR (95% CI) | p-value | |
Age (1 year increment) | 0.96 (0.92, 1.01) | 0.11 | – | – |
Male versus female gender | 1.9 (0.68, 5.5) | 0.22 | – | – |
Caucasian race | 1.04 (0.12, 9.3) | 0.97 | – | – |
Smoking | ||||
Ex-smoker versus non-smoker | 0.91 (0.37, 2.2) | 0.85 | – | – |
Current smoker versus non-smoker | 0.64 (0.15, 2.7) | 0.55 | – | – |
Current alcohol use | 3.0 (1.1, 8.0) | 0.027 | – | – |
Body mass index | 1.01 (0.94, 1.08) | 0.82 | – | – |
Aspirin | 2.0 (0.83, 5.0) | 0.12 | – | – |
NSAIDs | 6.8 (0.86, 883.1) | 0.2 | – | – |
Statins | 1.2 (0.50, 2.7) | 0.71 | – | – |
Proton pump inhibitors | 1.6 (0.01, 30.4) | 0.84 | – | – |
H2 blockers | 0.04 (0.00, 0.49) | 0.089 | – | – |
Hypertension | 0.50 (0.20, 1.2) | 0.14 | – | – |
Diabetes | 0.70 (0.25, 2.0) | 0.5 | – | – |
Hyperlipidemia | 1.7 (0.70, 3.9) | 0.26 | – | – |
History of fundoplication | 0.29 (0.05, 1.8) | 0.19 | – | – |
Length of Barrett’s segment (cm) | 0.90 (0.80, 1.02) | 0.092 | – | – |
Size of hiatal hernia (cm) | 0.92 (0.73, 1.2) | 0.46 | – | – |
Baseline biopsy | ||||
Cancer versus dysplasia | 0.21 (0.08, 0.52) | < 0.001 | 0.24 (0.09, 0.63) | 0.004 |
RFA versus cryotherapy | 1.9 (0.78, 4.6) | 0.16 | 1.7 (0.66, 4.3) | 0.28 |
Num. of treatment sessions | 1.04 (0.85, 1.3) | 0.72 | – | – |
Months from baseline to last endoscopy (1 month increment) | 1.03 (1.00, 1.05) | 0.031 | 1.03 (1.00, 1.05) | 0.039 |
CI confidence interval, NSAID nonsteroidal anti-inflammatory drugs, OR odds ratio, RFA radiofrequency ablation