TABLE 2.
Adjusted neurodevelopment composite scores at 18-mo corrected age assessed by the Bayley Scales of Infant and Toddler Development, Third Edition1
| Adjusted mean (95% CI)2 | Adjusted: model 12 | Adjusted: model 23 | ||||
|---|---|---|---|---|---|---|
| HMBF | BMBF | Effect (95% CI) | P value | Effect (95% CI) | P value | |
| Composite scores4 | ||||||
| Cognitive | 94.7 (90.9, 98.5) | 95.9 (91.7, 100.0) | −1.2 (−6.7, 4.4) | 0.67 | −1.1 (−6.5, 4.4) | 0.70 |
| Language | 92.4 (87.8, 97.1) | 93.1 (88.0, 98.2) | −0.7 (−7.4, 6.1) | 0.85 | −1.2 (−7.5, 5.1) | 0.70 |
| Motor | 95.6 (92.0, 99.2) | 97.7 (93.8, 101.5) | −2.1 (−7.3, 3.1) | 0.43 | −1.1 (−6.3, 4.2) | 0.69 |
Sample sizes for HMBF and BMBF groups, respectively: model 1: cognitive (59, 50), language (58, 48), motor (58, 50), and model 2: cognitive (57, 50), language (57, 48), motor (56, 50).
Adjusted using covariates from model 1 – birth weight strata (<1000 g and 1000–1249 g).
Adjusted using covariates from model 2 – birth weight strata (<1000 g or 1000–1249 g), sex, small for gestational age (y/n), maternal education (high school or less, college or vocational diploma, baccalaureate, postbaccalaureate), income above or below the poverty line (y/n below family size-adjusted poverty line), and any donor milk intake (y/n). Data was missing for maternal education (n = 1) and income above or below the poverty line (n = 1, also missing data for the language subtest) both in the HMBF group.
Standardized mean is 100 (SD 15). Variables were analyzed with linear regression, with adjustments as indicated. All models were tested for treatment interactions. Interaction terms were removed from the model if not statistically significant.
BMBF, bovine milk-based fortifier group; HMBF, human milk-based fortifier group.