Table 4. Association between ANAs and IAS burden among different ages.

	Age		Single IAS vs No IAS		IAS ≥2 vs No IAS
			OR (95% CI)	P value	OR (95% CI)	P value
ANAs (+) vs ANAs (-)	Age≤60 (n=485)	Crude OR	3.531(2.091, 5.961)	<0.001	3.852(1.967, 7.540)	<0.001
		Adjusted OR1	4.027 (2.308, 7.026)	<0.001	4.536(2.104,9.781)	<0.001
		Adjusted OR2	3.855 (1.625, 9.144)	0.002	5.655(1.574,20.324)	0.008
	60<Age≤75 (n=1173)	Crude OR	1.085(0.776,1.516)	0.634	3.074(2.187, 4.320)	<0.001
		Adjusted OR1	1.217(0.858,1.725)	0.271	4.163(2.822, 6.142)	<0.001
		Adjusted OR2	1.038(0.660,1.631)	0.872	4.393 (2.674,7.216)	<0.001
	Age>75 (n=834)	Crude OR	1.221(0.801,1.862)	0.354	2.491(1.699,3.651)	<0.001
		Adjusted OR1	1.238(0.802,1.911)	0.336	3.034 (2.004,4.592)	<0.001
		Adjusted OR2	0.831 (0.445,1.550)	0.560	4.083 (2.245, 7.423)	<0.001

IAS, Intracranial arterial stenosis; ANAs, antinuclear antibodies; OR, odds ratio; CI, confidence interval; Adjusted OR1, adjusted for age, gender, MAP, stroke history, hypertension, diabetes mellitus, coronary heart disease, atrial fibrillation, hyperuricemia, smoking habits and drinking habits; Adjusted OR2, adjusted for the items in OR1 plus blood glucose, serum uric acid, serum homocysteine, serum triglyceride, serum cholesterol, serum high density lipoprotein, serum low density lipoprotein, neutrophil and lymphocyte counts.