Table 5. Association between the number and grade of positive ANAs and IAS burden.

		Single IAS vs No IAS		IAS ≥2 vs No IAS
		OR (95% CI)	P value	OR (95% CI)	P value
ANAs-Count	Crude OR	1.080 (0.709, 1.646)	0.719	1.091 (0.733, 1.625)	0.668
	Adjusted OR1	1.239 (0.807, 1.903)	0.327	1.159 (0.731, 1.839)	0.530
Adjusted OR2	1.099 (0.599, 2.019)	0.760	1.545 (0.892, 2.675)	0.121
ANAs -Max	Crude OR	0.978 (0.809, 1.183)	0.819	0.928 (0.778, 1.107)	0.406
	Adjusted OR1	0.989 (0.811, 1.205)	0.910	1.004(0.826, 1.221)	0.965
	Adjusted OR2	0.899 (0.688, 1.175)	0.436	0.897 (0.694, 1.160)	0.408

IAS, Intracranial arterial stenosis; ANAs, antinuclear antibodies; OR, odds ratio; CI, confidence interval; ANAs-Count: the number of positive antinuclear antibody items in ANAs positive individuals; ANAs-Max: the highest grade of positive ANAs in ANAs positive individuals (+=1, ++=2, +++=3); Adjusted OR1, adjusted for age, gender, MAP, stroke history, hypertension, diabetes mellitus, coronary heart disease, atrial fibrillation, hyperuricemia, smoking habits and drinking habits; Adjusted OR2, adjusted for the items in OR1 plus blood glucose, serum uric acid, serum homocysteine, serum triglyceride, serum cholesterol, serum high density lipoprotein, serum low density lipoprotein, neutrophil and lymphocyte counts. Dependent variable: the IAS burden (no IAS, single IAS, IAS≥2); Independent variables: the ANAs-Count and ANAs-Max; The reference category is ‘No IAS’.