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. 2020 Jan 25;12(2):1304–1321. doi: 10.18632/aging.102684

Figure 6.

Figure 6

Inhibition of AURKB kinase activity represses the expression of CCND1 and decreases gastric cancer growth in vivo. (A) Photograph of xenograft tumors excised from mice treated with AZD1152 (25 mg/kg). (B) Tumor volumes were examined on the indicated days. Data are presented as the means ± SDs; **, P < 0.01. (C) Tumor mass of xenograft tumors excised from mice treated with AZD1152 (25 mg/kg). (D) Western blot analysis of AURKB, CCND1 and H3S10ph expression in xenograft tumors treated with AZD1152 (25 mg/kg). HSP70 and histone H3 were used as the endogenous controls. (E) Hematoxylin and eosin (H&E) staining and IHC staining of AURKB, CCND1, H3S10ph and Ki-67 in xenograft tumors excised from mice treated with AZD1152 (25 mg/kg) and control.