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. 2020 Jan 24;12(2):1237–1255. doi: 10.18632/aging.102680

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Copyright © 2020 Jiang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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ZEB1-AS1/miR-133b/HOXB8 contributed to CCA tumorigenesis in vivo. (A) Xenograft tumors were resected on the 21^st day after injection. (B) Tumor volumes were calculated every 3 days throughout the course of tumor growth. (C) CCLP-1 cells cotransfected with sh-ZEB1-AS1 and antagomir-133b were subcutaneously injected into the posterior flanks of mice. (D) Tumor weights were measured after excision. (E, F) HOXB8 expression in xenograft tumors of the three groups (sh-NC/antagomir-NC, sh-ZEB1-AS1/antagomir-NC, sh-ZEB1-AS1/antagomir-133b). ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.