Table 2. Univariate cox regression analysis of key genes.
| Variable | Univariate analysis (OS) | Univariate analysis (DFS) | |||||
| HR | 95%CI | P-value | HR | 95%CI | P-value | ||
| TOP2A | 1.774 | 1.305-2.413 | 0.000 | 1.906 | 1.321-2.749 | 0.001 | |
| NUF2 | 1.840 | 1.353-2.503 | 0.000 | 1.673 | 1.169-2.394 | 0.005 | |
| KIF4A | 1.984 | 1.456-2.702 | 0.000 | 1.942 | 1.350-2.794 | 0.000 | |
| HJURP | 2.594 | 1.879-3.579 | 0.000 | 2.138 | 1.487-3.075 | 0.000 | |
| FOXM1 | 2.118 | 1.550-2.894 | 0.000 | 2.026 | 1.407-2.917 | 0.000 | |
| CDCA8 | 2.052 | 1.500-2.806 | 0.000 | 1.954 | 1.359-2.810 | 0.000 | |
| CDCA5 | 2.027 | 1.482-2.771 | 0.000 | 1.896 | 1.320-2.725 | 0.001 | |
| CDC45 | 1.894 | 1.395-2.573 | 0.000 | 1.530 | 1.071-2.185 | 0.019 | |
| ISG20 | 1.652 | 1.219-2.239 | 0.001 | 1.703 | 1.188-2.441 | 0.004 | |
| Age | 1.750 | 1.288-2.378 | 0.000 | 1.363 | 0.957-1.942 | 0.086 | |
| Gender | 0.942 | 0.692-1.282 | 0.704 | 1.427 | 0.960-2.120 | 0.079 | |
| T stage | 1.901 | 1.615-2.237 | 0.000 | 2.506 | 2.033-3.089 | 0.000 | |
| N stage | 3.847 | 2.083-7.107 | 0.000 | 5.731 | 2.874-11.428 | 0.000 | |
| M stage | 4.295 | 3.149-5.856 | 0.000 | 8.628 | 5.944-12.524 | 0.000 | |
| TNM stage | 1.875 | 1.645-2.138 | 0.000 | 2.668 | 2.238-3.180 | 0.000 | |
| Grade | 2.250 | 1.842-2.748 | 0.000 | 3.028 | 2.348-3.905 | ||
OS: overall survival; DFS: disease-free survival; HR: hazard ratio; CI: confidence interval; TNM: Tumor Node Metastasis.