Table 2. Association of cardiovascular function parameters and cerebrovascular changes.

	Better cardiovascular function	Worse cardiovascular function
	Pulse wave velocity ≤10m/s n = 45	Pulse wave velocity >10m/s n = 38	p-value
			Crude	Adjusted
Presence of microbleeds, %
Non-lobar	7 (16.7)	11 (28.9)	0.189	0.575
Lobar	13 (31.0)	18 (47.4)	0.132	0.105
Presence of lacunes, %	18 (42.9)	19 (50.0)	0.522	0.616
Total WMH, mean ± SE	15.5 ± 1.2	16.6 ± 1.4	0.561	0.438
	Ejection fraction ≥50% n = 65	Ejection fraction <50% n = 19
Presence of microbleeds, %
Non-lobar	13 (20.6)	5 (27.8)	0.520	0.563
Lobar	22 (34.9)	10 (55.6)	0.114	0.121
Presence of lacunes, %	29 (46.0)	10 (55.6)	0.476	0.767
Total WMH, mean ± SE	15.8 ± 0.9	16.9 ± 2.4	0.609	0.778
	Cardiac index >2.2l/min/m2 n = 56	Cardiac index ≤2.2l/min/m2 n = 27
Presence of microbleeds, %
Non-lobar	13 (23.6)	5 (20.0)	0.718	0.457
Lobar	23 (41.8)	8 (32.0)	0.403	0.382
Presence of lacunes, %	28 (50.9)	10 (40.0)	0.365	0.443
Total WMH, mean ± SE	17.0 ± 1.2	14.2 ± 1.3	0.151	0.166

P-values are assessed using linear or logistic regression models, unadjusted and adjusted for age and sex, comparing low versus high pulse wave velocity, ejection fraction and cardiac index.

Lacunes include both gliotic and hemorrhagic parenchymal defects subcortical, in brain stem and basal ganglia.

Abbreviations: SE, standard error; WMH, white matter hyperintensities.