Table 3. Association between soluble Klotho levels and other factors.
| A) Univariate correlation analysis | Full-study group (n=132) | Age-matched subgroup* (n=60) | ||
| Variable | r | P-value | r | P-value |
| Age | -0.261 | <0.01 | 0.047 | NS |
| BMI | -0.134 | 0.13 | -0.255 | 0.06 |
| eGFR | 0.217 | <0.05 | 0.250 | 0.07 |
| Creatinine | -0.138 | 0.12 | -0.160 | NS |
| Albumin | -0.026 | NS | -0.087 | NS |
| Calcium | 0.153 | 0.08 | 0.172 | NS |
| Phosphorus | 0.110 | NS | 0.130 | NS |
| Uric acid | 0.041 | NS | 0.219 | 0.12 |
| Glucose | 0.075 | NS | 0.140 | NS |
| Total cholesterol | 0.163 | 0.07 | 0.248 | 0.08 |
| HDL | 0.039 | NS | 0.162 | NS |
| NLR | -0.015 | NS | 0.172 | NS |
| CRP | -0.203 | <0.05 | -0.235 | 0.13 |
| TNFα | -0.035 | NS | 0.074 | NS |
| IL10 | 0.209 | <0.05 | 0.278 | <0.05 |
| TNFα/IL10 | -0.219 | <0.05 | -0.256 | <0.05 |
| B) Multiple regression analysis | Full-study group (n=132) | Age-matched subgroup*(n=60) | ||||||||
| Variable | Adj-R2 | β | SE | t | P-value | Adj-R2 | β | SE | t | P-value |
| Adjusted R2 | 0.068 | <0.05 | 0.232 | <0.05 | ||||||
| Age | -0.234 | 0.002 | -2.327 | <0.05 | 0.065 | 0.007 | 0.346 | NS | ||
| Sex | -0.006 | 0.048 | -0.067 | NS | -0.124 | 0.073 | -0.636 | NS | ||
| Total cholesterol | 0.067 | 0.000 | 0.714 | NS | 0.345 | 0.001 | 1.937 | 0.07 | ||
| NLR | 0.058 | 0.009 | 0.653 | NS | 0.262 | 0.035 | 1.414 | 0.17 | ||
| TNFα/IL10 | -0.243 | 0.026 | -2.621 | <0.01 | -0.411 | 0.059 | -2.355 | <0.05 | ||
| Smoker | -0.105 | 0.047 | -1.124 | NS | ||||||
| HT | -0.10 | 0.049 | -0.105 | NS | ||||||
| DM | -0.10 | 0.041 | -0.102 | NS | ||||||
| Phosphorus | 0.046 | 0.040 | 0.518 | NS | ||||||
| Uric acid | 0.19 | 0.014 | 0.209 | NS | ||||||
BMI, body mass index; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; NLR, neutrophil-to-lymphocyte ratio; CRP, c-reactive protein; TNFα, tumor necrosis factor alpha; IL10, interleukin 10; HT, hypertension; DM, diabetes mellitus; NS, not significant. *_ Age-matched subgroup (2 CVD:1 non-CVD).