Table 3. Cox regression analyses of genetic risk factors for PFS in MBC patients.
| Covariates | Level | Univariate Cox Model | Multivariate Cox Model | |||
| HR (95% CI) | p-value | HR (95% CI) | p-value | |||
| PI3K/AKT pathway | WT | Ref | Ref | |||
| mutations | PIK3CA-HD | 2.99 (1.64, 5.44) | 0.0004 | 2.00 (1.02, 3.93) | 0.045 | |
| PIK3CA-KD | 1.22 (0.72, 2.09) | 0.45 | 0.75 (0.39, 1.42) | 0.37 | ||
| PIK3CA-OD | 0.64 (0.23, 1.80) | 0.39 | 0.40 (0.14, 1.18) | 0.10 | ||
| P/A | 0.95 (0.49, 1.85) | 0.88 | 0.80 (0.40, 1.57) | 0.51 | ||
| TP53 aberration | No | Ref | Ref | |||
| Yes | 2.25 (1.43, 3.54) | 0.0004 | 2.22 (1.35, 3.66) | 0.002 | ||
| ERBB2 aberration | No | Ref | Ref | |||
| Yes | 1.54 (0.93, 2.55) | 0.09 | 1.45 (0.80, 2.65) | 0.23 | ||
| FAT1 aberration | No | Ref | Ref | |||
| Yes | 2.06 (1.06, 4.00) | 0.03 | 1.48 (0.74, 2.98) | 0.27 | ||
| ESR1 aberration | No | Ref | Ref | |||
| Yes | 1.16 (0.56, 2.43) | 0.69 | 1.25 (0.58, 2.71) | 0.60 | ||
| DNMT3A aberration | No | Ref | Ref | |||
| Yes | 1.05 (0.54, 2.04) | 0.88 | 0.93(0.45, 1.91) | 0.84 | ||
| FGFR aberration | No | Ref | Ref | |||
| Yes | 1.87 (1.05, 3.33) | 0.03 | 2.17 (1.17, 4.02) | 0.01 | ||
| NF1 aberration | No | Ref | Ref | |||
| Yes | 1.03 (0.38, 2.81) | 0.96 | 0.6 (0.30, 1.56) | 0.37 | ||
| TMB index | Low | Ref | Ref | |||
| High | 1.94 (1.19, 3.16) | 0.008 | 1.62 (1.00, 2.66) | 0.05 | ||
| Unknown | 0.73 (0.36, 1.47) | 0.38 | 0.88 (0.43, 1.79) | 0.72 | ||