Figure 1.

The activation and mitochondrial translocation of Drp1 in IECs after shock or hypoxia. (A) The mitochondrial translocation of Drp1 after hemorrhagic shock in colon tissues. N_WT, WT mice in normal condition; HS_WT, WT mice in hemorrhagic shock condition. (n=5 mice/ group) (B) Post-translational modifications of Drp1 after hemorrhagic shock detected by co-immunoprecipitation. N, N_WT group; HS, HS_WT group; Phosphor-, Phosphorylation; Ubiquitin-, ubiquitination; SUMO-, SUMOylation. (n=5 mice/ group) (C) The phosphorylation of Drp1 after hemorrhagic shock in colon tissues detected by Western Blotting. (n=5 mice/ group) (D) The co-location of Drp1 and mitochondria after CoCl₂-induced hypoxia in IECs. (Bar, 25μm) (n=5). a represents p < 0.05 compared with N_WT group or Normal group.