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. Author manuscript; available in PMC: 2020 Mar 3.
Published in final edited form as: Chem Res Toxicol. 2019 Sep 11;32(10):1997–2005. doi: 10.1021/acs.chemrestox.9b00149

Figure 8.

Figure 8.

APZ increases O3-induced IL-6 and IL-8 gene expression in a sex-specific manner in primary human nasal epithelial cells. Human nasal epithelial cells grown at ALI were treated in the basolateral compartment with l|iM APZ for 3 days prior to 0.4 ppm O3 exposure, and RNA was collected 1 h postexposure. Treatment with APZ significantly enhanced expression of (A) IL-6 and (B) IL-8 in nasal epithelial cells from males, but not females as compared to the DMSO control. n = 2–3. Data are presented as individual data points.