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. 2019 Aug 20;10(10):1828–1837. doi: 10.1039/c9md00306a

Table 2. Inhibitory activity of compounds 9d–e and 10k on the HDAC nuclear extract at 0.5 μM.

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Compd. R1 R2 Inhibition% log P
9d CH3CH2 NHCO- 4′-OCH3 51% 2.85
9e CH3CH2 NHCO- 4′-OH 21% 2.53
10k 4-F–Ph(CH2)2NHCO- 4′-OCH3 53% 4.16
10l 4-F–Ph(CH2)2CONH- 4′-OCH3 49% 4.52
SAHA — — 46% 1.88