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. 2020 Mar 3;15(3):e0229729. doi: 10.1371/journal.pone.0229729

Fig 2. Algorithm used in the model to automatically estimate the parameters of LD pharmacodynamics, via minimization of a cost function.

Fig 2

It is worth-noting that a similar algorithm has been previously used to estimate the pharmacokinetics (PK) parameters too, to model the temporal pattern of plasma dopamine concentration.