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. 2020 Feb 28;14:907–919. doi: 10.2147/DDDT.S223646

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© 2020 He et al.

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Roles of TCM in M1-TAMs and M2-TAMs.

Notes: TCM have effects on tumor cells by targeting M1 phenotype and M2 phenotype TAMs. ① TCM treatment could increase the population of M1-TAMs through increasing M1 polarization. ② Number of M2-TAMs decrease because TCM block the polarization of TAMs to M2 phenotype. ③ TCM reverse the phenotype of TAMs from M2 to M1. ④ Monochrome M2-TAMs means the protumoral capacities of M2-TAMs are suppressed.

Abbreviations: TCM, traditional Chinese medicine; TAMs, tumor-associated macrophages; M2-TAMs, M2-polarized tumor-associated macrophages; M1-TAMs, M1-polarized tumor-associated macrophages.