Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Feb 28;12:1503–1512. doi: 10.2147/CMAR.S233028

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Zhao et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

OTUD4 inhibits tumor cell proliferation and promotes tumor cell apoptosis. (A) Construction of cell lines with overexpression of OTUD4 in breast cancer, liver cancer and lung cancer cells. Representative Real Time PCR and Western blot analysis shows the results of OTUD4 overexpression in MDA-MB-231, ZR-75-30, HepG2, Huh7, A549 and H460 cancer cells. (B) Overexpression of OTUD4 inhibits the proliferation of breast cancer, liver cancer and lung cancer cells. The MTT assay indicates that the growth rates decreased in OTUD4-transduced cancer cells. *P< 0.01. (C) Overexpression of OTUD4 promotes apoptosis of breast cancer, liver cancer and lung cancer cells. GSEA plot showing that OTUD4 expression is positively correlated with Genes mediating programmed cell death (apoptosis) by activation of caspases signature (HALLMARK_APOPTOSIS) in published breast cancer patient gene expression profiles (NCBI/GEO/GSE42568, n=121), liver cancer patient gene expression profiles (NCBI/GEO/GSE26566, n=169) and lung cancer patient gene expression profiles (NCBI/GEO/GSE3141, n=111).