Fig. 4.
Increased hepatic cholesterol content in Cyp2c70ako mice is reversed by pharmacological FXR activation. Liver weight (A), hepatic content of triglycerides (B), phospholipids (C), free cholesterol (D), and cholesteryl esters (E) in chow-fed Cyp2c70ako mice and controls (CTRL) as well as after treatment with the FXR agonist PX (10 mg/kg/day) in the diet for 18 days (n = 6–8 animals per group). *P < 0.05, **P < 0.01, ***P < 0.001 (Kruskal-Wallis H test, followed by Conover post hoc comparisons). CTRL, control.