TABLE 3.
Hepatic lipid content and liver function parameters measured in plasma
| Vehicle | PX | |||
| Control (n = 8) | Cyp2c70ako (n = 6) | Control (n = 6) | Cyp2c70ako (n = 7) | |
| Total cholesterol (mmol/l) | 2.71 (2.37–3.63) | 2.75 (2.57–2.84) | 2.49 (2.12–2.80) | 2.40 (1.61–3.09) |
| Free cholesterol (mmol/l) | 0.98 (0.88–1.43) | 1.19 (0.96–1.52) | 1.00 (0.79–1.31) | 0.90 (0.66–1.42) |
| Cholesteryl esters (mmol/l) | 1.72 (1.33–2.26) | 1.58 (1.05–1.75) | 1.33 (1.21–1.75) | 1.41 (0.95–1.68) |
| Triglycerides (mmol/l) | 1.27 (0.66–2.89) | 1.61 (0.71–2.10) | 0.95 (0.72–1.77) | 1.12 (0.61–1.54) |
| Free fatty acids (mmol/l) | 0.20 (0.08–0.36) | 0.17 (0.15–0.74) | 0.32 (0.15–0.56) | 0.28 (0.22–0.52) |
| Alanine aminotransferase (U/l) | 76 (42–141) | 149 (91–180)a | 77 (21–143) | 145 (56–293) |
| Aspartate aminotransferase (U/l) | 32 (18–64) | 49 (36–60)a | 24 (20–38) | 49 (17–86)a |
Values are presented as median (range) of male mice.
a
P < 0.05 versus control (Kruskal-Wallis H test, followed by Conover post hoc comparisons).