Fig. 5.

Nobiletin improves glucose and insulin tolerance, decreases hepatic steatosis, and enhances hepatic FA oxidation in both HFHC diet-fed AccDKI and WT mice. WT and AccDKI mice were fed a HFHC diet (HF) alone or a HFHC diet plus nobiletin (+Nob) for 18 weeks, n = 6 per group. A: Blood glucose concentrations. B: iGTT. C: AUC for iGTT. D: Plasma insulin concentrations. E: ITT, as percent of baseline glucose. F: AUC for ITT. G: Hepatic TG concentrations. H: Hepatic FC and CE concentrations. I: Hepatic FA oxidation. Data represent the mean ± SEM. Different letters indicate statistical differences by ANOVA with post hoc Tukey’s test (P < 0.05). N.S., no significant difference.