Fig. 2.

Triple treatment with alirocumab and evinacumab on top of atorvastatin regresses pre-existent lesions and reduces aortic lipid content in the thoracic aorta. En face analysis of atherosclerosis (A) and lipid content (B) in the thoracic aorta with representative images (C). Bars with different letters indicate statistical difference (P < 0.05). Data are presented as mean ± SEM (n = 12 per group). A, atorvastatin; ali, alirocumab; CE, cholesterol ester; evin, evinacumab; FC, free cholesterol.