Fig. 3.

Double treatment with alirocumab or evinacumab on top of atorvastatin blocks the progression of atherosclerosis and triple treatment regresses pre-existent lesions in the aortic root. Lesion size in the aortic root after 13 weeks of WTD (baseline) and in control and treatment groups at end-point (week 38) (A). Number of lesions per cross-section was assessed and average size per lesion was calculated (B). Lesion severity as relative amount of mild and complex lesions together with lesion-free segments (C). Representative images (D). Bars with different letters indicate statistical difference (P < 0.05). Data are presented as mean ± SEM (n = 13–16 per group). A, atorvastatin; ali, alirocumab; evin, evinacumab.