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. 2020 Feb 7;45(4):1176–1186. doi: 10.3892/ijmm.2020.4493

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Copyright: © Fu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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CORM-3 ameliorates upregulation in pyroptosis in the hippocampus. (A) Representative photomicrographs of cleaved caspase-1/NeuN/DAPI staining (cleaved caspase-1, red; NeuN, green; DAPI, blue) demonstrating pyroptotic cells in the hippocampal tissue induced by the indicated stimuli. Scale bar, 50 µm. (B) Percentages of pyroptotic cells in the hippocampal tissue induced by the indicated stimuli. Data are presented as the mean ± SD (n=6 per group). ^*P<0.05 vs. Sham; $P<0.05 vs. HSR vehicle and HSR iCORM-3. CORM, carbon monoxide-releasing molecule; HSR, hemorrhage shock and resuscitation; iCORM-3, inactive CORM-3.