Table 2.

Associations between cardiometabolic health, host genetic ancestry, and gut microbiota composition. Scaled regression coefficients, p-values, and q-values are shown for each cardiometabolic factor.

	Genetic ancestry						Gut microbiota composition
	PC1			PC2			PCo1			PCo2
	Scaled beta	P	q	Scaled beta	P	q	Scaled beta	P	q	Scaled beta	P	q
Lipid profile
HDL	0.80	0.42	0.34	−1.16	0.25	0.25	1.47	0.14	0.19	−0.18	0.86	0.56
LDL	0.49	0.62	0.42	−0.96	0.34	0.37	0.98	0.33	0.37	1.70	0.09	0.18
VLDL	−0.94	0.35	0.26	−1.20	0.23	0.22	−0.43	0.66	0.31	0.50	0.62	0.31
Total cholesterol	0.10	0.92	0.53	−1.78	0.08	0.12	1.35	0.18	0.19	1.47	0.14	0.19
Triglycerides	−0.96	0.34	0.22	−1.11	0.27	0.22	−0.38	0.7	0.32	0.53	0.60	0.30
Glucose metabolism
Fasting glucose	−1.24	0.21	0.16	−1.18	0.24	0.16	−1.29	0.20	0.16	−0.63	0.53	0.27
HbA1c	0.33	0.74	0.32	−1.32	0.19	0.17	−0.48	0.63	0.29	−0.50	0.62	0.29
Fasting insulin	−1.83	0.07	0.11	−2.62	0.01	0.02	−0.86	0.39	0.31	1.72	0.09	0.11
HOMA-IR	−0.19	0.85	0.75	1.35	0.18	0.63	−0.95	0.34	0.63	0.49	0.63	0.63
Pro-inflammatory state
hsCRP	0.89	0.37	1.00	0.00	1.00	1.00	−0.23	0.81	1.00	1.78	0.07	0.52
Blood pressure
Systolic	0.04	0.97	0.99	−0.36	0.72	0.92	−2.81	0.005	0.02	3.67	0.0002	0.001
Diastolic	1.03	0.30	0.38	−0.09	0.93	0.67	−2.15	0.03	0.08	3.49	0.0005	0.002
Body fat distribution
BMI	−0.07	0.94	0.69	−2.39	0.02	0.04	−1.45	0.15	0.29	3.92	<0.0001	0.0009
Waist circumference	−0.70	0.48	0.27	−1.62	0.11	0.13	−1.34	0.18	0.18	3.51	0.0004	0.0009
Body fat	−0.94	0.35	0.52	−1.61	0.11	0.18	−0.66	0.51	0.66	2.85	0.0004	0.01
Cardiometabolic health
CMS risk scale	−0.68	0.50	0.40	−1.99	0.05	0.06	−2.24	0.03	0.04	3.89	<0.0001	0.0003
Framingham score	0.05	0.96	0.96	0.20	0.84	0.94	0.58	0.57	0.94	3.22	0.001	0.004