Table 2.
Factors to regulate the formation of RhoA-RhoGDI complex.
| Factor | Function or feature | Reference |
|---|---|---|
| Ezrin/radixin/moesin | GDF | 18 |
| p75NTR | GDF | 19 |
| Phosphorylation of RhoGDI by Pak1 | Decrease of RhoGDI activity to bind to Rac1 | 20 |
| Phosphorylation of RhoGDI by Src | Decrease of RhoGDI activity to bind to RhoA, Rac1 and Cdc42 | 21 |
| Acetylation of RhoGDI | Decrease of RhoGDI activity to bind to RhoA | 22 |
| IKKγ/NEMO | GDF | 17 |
| Oxidation of RhoGDI | GDF | 24 |
| Oxidation of RhoA | GDF | 24 |
| Ser188 phosphorylation of RhoA by PKA, PKG, AMPK, ERK | Increase of RhoA binding to RhoGDI, Inactivation of RhoA | 31, 34-36 |
| Tyr42 phosphorylation of RhoA | GDF | 37 |
| Prion | Inactivation of RhoA | 27 |
Abbreviations: GDF, GDI displacement factor; NTR, neurtrophin receptor; Pak, p21-activated kinase; IKKγ, IκB kinase γ; GDI, guanine nucleotide dissociaition inhibitor; NEMO, NF-κB essential modulator; PKA, protein kinase A; PKG, protein kinase G, AMPK, AMP-dependent kinase.