Figure 1.

Schematic representation of MYC and MYC-nick. MYC is predominantly localized in the nucleus (outlined in red) where it drives the expression of genes that promote cell proliferation. MYC-nick is localized in the cytoplasm and promotes cell survival and migration. In conditions of stress (such as high cell density, hypoxia and nutrient starvation) calpain-mediated cleavage of MYC produces MYC-nick. (MB) MYC Box I-IV. BHLH-DNA binding and heterodimerization domain. (HAT) Histone Acetyl Transferases such as GCN5. PEST (proline, glutamic acid, serine and threonine-rich domain). (NLS) nuclear localization sequence.